Transcriptional Activity of Erythroid Kruppel-like Factor (EKLF/KLF1) Modulated by PIAS3 (Protein Inhibitor of Activated STAT3)

Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).

Smad proteins play pivotal roles in mediating the transforming growth factor beta (TGF-beta) transcriptional responses. We show in this report that PIAS3, a member of the protein inhibitor of activated STAT (PIAS) family, activates TGF-beta/Smad transcriptional responses. PIAS3 interacts with Smad proteins, most strongly with Smad3. PIAS3 and Smad3 interact with each other at the endogenous pro...

Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation

http://bloodjournal.hematologylibrary.org/content/97/6/1861.full.html Updated information and services can be found at: (1174 articles) Red Cells • (3094 articles) Hematopoiesis and Stem Cells • (1086 articles) Gene Expression • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Informatio...

Recombinant erythroid Kruppel-like factor fused to GATA1 upregulates globin expression in erythroid cells

TRIM8 modulates STAT3 activity through negative regulation of PIAS3.

TRIM8 is a member of the protein family defined by the presence of a common domain structure composed of a tripartite motif: a RING-finger, one or two B-box domains and a coiled-coil motif. Here, we show that TRIM8 interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL-6-dependent activation of STAT3. Ectopic expression of TRIM8 cancels the negative effect of PIAS3 on ST...

Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6.

Nitric oxide is a ubiquitous free radical that plays a key role in a broad spectrum of signaling pathways in physiological and pathophysiological processes. We have explored the transcriptional regulation of inducible nitric-oxide synthase (iNOS) by Krüppel-like factor 6 (KLF6), an Sp1-like zinc finger transcription factor. Study of serial deletion constructs of the iNOS promoter revealed that ...